Sediaan Face Mist Fraksi Kulit Manggis (Garcinia Mangostana L.) Sebagai Antibakteri Propionibacterium Acnes
DOI:
https://doi.org/10.67721/jf.v1i1.16Keywords:
antibakteri, face mist, Garcinia mangostana L, kulit manggis, Propionibacterium acnes, antibacterial, mangosteen peelAbstract
Jerawat (acne vulgaris) merupakan masalah kulit yang sering disebabkan oleh pertumbuhan bakteri Propionibacterium acnes. Penggunaan antibiotik jangka panjang dapat menyebabkan resistensi bakteri sehingga diperlukan alternatif bahan alam yang memiliki aktivitas antibakteri. Salah satu bahan alam yang berpotensi dikembangkan adalah kulit manggis (Garcinia mangostana L.) karena mengandung metabolit sekunder yang berpotensi sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui kandungan metabolit sekunder fraksi kulit manggis, memformulasikannya ke dalam sediaan face mist, serta mengevaluasi aktivitas antibakterinya terhadap Propionibacterium acnes. Penelitian ini merupakan penelitian eksperimental laboratorium dengan metode difusi cakram (disk diffusion). Sediaan face mist dibuat dalam empat formula, yaitu F0 (0%), F1 (1%), F2 (3%), dan F3 (5%). Skrining fitokimia menunjukkan adanya kandungan flavonoid, alkaloid, tanin, saponin, dan terpenoid, sedangkan steroid tidak terdeteksi. Hasil uji antibakteri menunjukkan bahwa F0 tidak memiliki daya hambat (0.00 ± 0.00 mm), sedangkan F1, F2, dan F3 menghasilkan rata-rata diameter zona hambat masing-masing sebesar 18.33 ± 0.14 mm, 24.47 ± 0.43 mm, dan 28.17 ± 0.51 mm. Hasil analisis statistik menunjukkan adanya pengaruh signifikan variasi konsentrasi fraksi kulit manggis terhadap aktivitas antibakteri (p < 0,05). Formula terbaik diperoleh pada F3 (5%) karena menghasilkan daya hambat terbesar terhadap Propionibacterium acnes. Dengan demikian, sediaan face mist fraksi kulit manggis berpotensi dikembangkan sebagai alternatif kosmetik anti jerawat berbasis bahan alam.
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