Uji Efektivitas Antibakteri Ekstrak Rimpang Kunyit Curcuma Domestica Terhadap Bakteri Escherichia Coli
DOI:
https://doi.org/10.67721/jf.v1i1.20Keywords:
kunyit, Curcuma domestica, antibakteri, Escherichia coli, zona hambatAbstract
Escherichia coli merupakan bakteri patogen yang dapat menyebabkan berbagai penyakit infeksi, seperti diare, infeksi saluran kemih, dan gangguan gastrointestinal, serta memiliki kecenderungan meningkat terhadap resistensi antibiotik. Oleh karena itu, diperlukan alternatif antibakteri berbasis bahan alam, salah satunya rimpang kunyit (Curcuma domestica) yang diketahui mengandung senyawa bioaktif seperti kurkumin, flavonoid, tanin, saponin, dan terpenoid. Penelitian ini bertujuan untuk mengetahui efektivitas antibakteri ekstrak rimpang kunyit terhadap pertumbuhan bakteri Escherichia coli. Penelitian menggunakan metode eksperimen laboratorik dengan teknik difusi cakram pada beberapa kelompok perlakuan (P1–P5), kontrol positif [K(+)] dan kontrol negatif [K(-)]. Hasil penelitian menunjukkan rerata diameter zona hambat meningkat seiring bertambahnya konsentrasi ekstrak, yaitu P1 sebesar 8,03 mm, P2 sebesar 9,15 mm, P3 sebesar 11,00 mm, P4 sebesar 12,60 mm, dan P5 sebesar 18,10 mm. Kontrol positif menunjukkan rerata zona hambat sebesar 19,85 mm, sedangkan kontrol negatif tidak menunjukkan zona hambat (0 mm). Disimpulkan bahwa ekstrak rimpang kunyit memiliki efektivitas antibakteri terhadap Escherichia coli, dengan aktivitas tertinggi pada perlakuan P5.
References
Amalraj, A., Pius, A., Gopi, S., & Gopi, S. (2017). Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives: A review. Journal of Traditional and Complementary Medicine, 7(2), 205–233.
Brooks, G. F., Carroll, K. C., Butel, J. S., Morse, S. A., & Mietzner, T. A. (2023). Jawetz, Melnick & Adelberg’s Medical Microbiology (29th ed.). New York: McGraw-Hill Education.
Gupta, S. C., Patchva, S., Koh, W., & Aggarwal, B. B. (2013). Discovery of curcumin, a component of golden spice, and its miraculous biological activities. Clinical and Experimental Pharmacology and Physiology, 40(7), 463–480.
Gupta, V., Sharma, N., & Singh, A. (2021). Antibacterial activity of turmeric (Curcuma domestica) extract against pathogenic bacteria. International Journal of Pharmaceutical Sciences Review and Research, 68(2), 54–61.
Harborne, J. B. (1998). Phytochemical Methods: A Guide to Modern Techniques of Plant Analysis (3rd ed.). London: Chapman and Hall.
Hewlings, S. J., & Kalman, D. S. (2017). Curcumin: A review of its effects on human health. Foods, 6(10), 92.
Jawetz, E., Melnick, J., & Adelberg, E. (2020). Medical Microbiology (28th ed.). New York: McGraw-Hill Education.
Kaper, J. B., Nataro, J. P., & Mobley, H. L. T. (2004). Pathogenic Escherichia coli. Nature Reviews Microbiology, 2(2), 123–140.
Kementerian Kesehatan Republik Indonesia. (2023). Farmakope Herbal Indonesia Edisi III. Jakarta: Kementerian Kesehatan RI.
Molton, J. S., Tambyah, P. A., Ang, B. S. P., Ling, M. L., & Fisher, D. A. (2020). The global spread of antimicrobial resistance among common bacterial pathogens. Clinical Infectious Diseases, 71(4), 890–898.
Negi, P. S., Jayaprakasha, G. K., Jagan Mohan Rao, L., & Sakariah, K. K. (1999). Antibacterial activity of turmeric oil: A byproduct from curcumin manufacture. Journal of Agricultural and Food Chemistry, 47(10), 4297–4300.
Pelczar, M. J., & Chan, E. C. S. (2019). Dasar-Dasar Mikrobiologi. Jakarta: UI Press.
Prasad, S., & Aggarwal, B. B. (2011). Turmeric, the golden spice: From traditional medicine to modern medicine. In Herbal Medicine: Biomolecular and Clinical Aspects (2nd ed.). Boca Raton: CRC Press.
Pratiwi, S. T. (2017). Mikrobiologi Farmasi. Jakarta: Erlangga.
Rai, M., Ingle, A. P., Pandit, R., Paralikar, P., Gupta, I., Chaud, M. V., & Santos, C. A. (2020). Broad-spectrum bioactivities of curcumin: Current status and future perspectives. Phytotherapy Research, 34(5), 842–859.
Salehi, B., Stojanović-Radić, Z., Matejić, J., Sharifi-Rad, M., Kumar, N. V. A., Martins, N., & Sharifi-Rad, J. (2019). The therapeutic potential of curcumin: A review of clinical trials. European Journal of Medicinal Chemistry, 163, 527–545.
Tyagi, P., Singh, M., Kumari, H., Kumari, A., & Mukhopadhyay, K. (2015). Bactericidal activity of curcumin against pathogenic bacteria. Antimicrobial Agents and Chemotherapy, 59(11), 6933–6941.
Utami, P., & Puspaningtyas, D. E. (2021). Aktivitas antibakteri tanaman herbal Indonesia terhadap bakteri Gram negatif. Jurnal Biomedika, 13(2), 87–95.
Ventola, C. L. (2015). The antibiotic resistance crisis: Causes and threats. Pharmacy and Therapeutics, 40(4), 277–283.
World Health Organization. (2023). Global antimicrobial resistance and use surveillance system (GLASS) report 2023. Geneva: WHO.
Yuliani, N., Sari, D. P., & Kurniawan, A. (2022). Skrining fitokimia dan aktivitas antibakteri ekstrak rimpang kunyit terhadap bakteri Escherichia coli. Jurnal Ilmu Kefarmasian Indonesia, 20(1), 45–53.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 LENTERA PHARMASCIENCE: Pharmaceutical Journal
This work is licensed under a Creative Commons Attribution 4.0 International License.
Unduh Template (Indonesia) 
Download Template (English) 
